Cardoval

To calm heart stress
Special product for heart and blood circulation
KNOW ABOUT YOUR HEART IN ORDER TO HELP TO IT
Scientific information
Cardiovascular disorders are significant life threatening diseases.
Cardiovascular diseases are the major problem of healthcare in the new age. As progress goes on and level of living standard increase their incidence increase too.
According to investigations untreated hypertension 10-20 years shortens human's life, and myocardial infarction is one of the most common diagnoses at hospitalization. Every year ppproximately 1,5 million  people globally experience heart attack. Approximately 30 percent of patients die from this disease, of them
Cardiovascular disease risk factors
The following risk factors are common in many patients under 65 years with cardiovascular diseases:
- male sex,
- predisposition to early ischemic heart disease in the immediate family,
- hiperlipidemia (increase of blood lipid level),
- smoking,
- hypertension,
- low level of high density cholesterol and high level of low density cholesterol,
- obesity,
- hyperglycemia (increased blood glucose level).
In any case risk for cardiovascular diseases should be assessed and protective measures should be taken.
Necessary aid to your heart
It is important to choose special food supplement for cardiovascular system taking into account their active substances and their effects. Healthcare of the XXI century recognize that the extract of the common hawthorn fruits is an effective active substance for cardiovascular system.
Scientific research data confirm pharmacologic effect of the extract of the common hawthorn fruits. Hawthorn preparations are recommended to use as restorative medication improving the action of cardiovascular system. Pharmacological research showed that hawthorn medications improve myocardial blood flow and contractions, regulate heart rate, lower tone of peripheral blood vessels, and improve myocardium resistance to hypoxia.
Cholesterol and lipid blood levels must be normalized in order to improve the action of cardiovascular system. Garlic possesses antimicrobial, lipid level lowering, fibrinolytic and platelet aggregation suppressing properties.
Active substances improving action of the cardiovascular system and their effects
Extract of the common hawthorn (Crataegus). Stimulate blood flow in the coronary arteries and myocardium. Due to effect on the more important for nutrition, strength and its release parts of the myocardium heart becomes stronger. Hawthorn increases the power of heart contractions, normalizes heart rate, and therefore heart power increases. The extract eliminates sense of pressure and heaviness in the heart region, normalizes increased heart rate of arrhythmia, and reduces dyspnoe during physical load. Blood flow becomes more stable, and physical capacity increase.
Magnesium reduces cardiovascular disease incidence: it reduces blood pressure (especially systolic), widens coronary arteries, and improve cell supply with oxygen. It reduces risk of ventricular arrhythmias (e.g., after surgery).
Extract of the green tea (Camellia sinensis). It is potent antioxidant containing bioflavonoids. It prevents from the formation of free radicals, reduces cholesterol blood level, improves memory, accelerates metabolism, helps to burn lipids, and improves physical and mental activity and concentration. Preparation promotes metabolism, and therefore is widely used in cases of overweight. Research confirmed that green tee extract helps to “burn” lipids.
Vitamin B6 (pyridoxine hydrochloride). It takes part in the metabolism of proteins and amino acids, in the synthesis of hormones, red blood cells, regulates cell reproduction and differentiation, strengthen immune system. It also reduces hypoxia of the myocardium.
Garlic (Allium sativum) oil.  It possesses antibacterial, lipid level reducing and antithrombotic effect, helps to reduce low density lipoprotein level and increase high density lipoprotein level. Active substances of garlic reduce platelet aggregation (adhesion), and therefore they prevent thrombus formation.
Active substances possessing the most positive effects on the cardiovascular system were selected according to the results of scientific research, and innovative formula of food supplement CARDOVAL was developed.

References:
1. Bernstein L, MD. Improving Magnesium Absorption and Bioavailability. Geriatric Times, 2002 January/February, Vol. III, Issue 1. http://www.cmellc.com/geriatrictimes/g020208.html
2. Brixius K, Willms S, Schwinger RHG. Zellulare und molekulare Wirkmechanismen von Crataegus–Extrakt [Cellular and Molecular Effects of Crataegus Extract]. Pharm Unserer Zeit. 2005, 34(1): 48-51.
3. Chang WT, Dao J, Shao ZH. Hawthorn: potential roles in cardiovascular disease. Am J Chin Med. Am J Chin med. 2005, 33(1): 1-10.
4. Degenring FH, Suter A, Weber M, Saller R. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in treatment of patients with congestive heart failure NYHA II.Phytomedicine. 2003, 10(5):363-369.
5. Holubarsch CJF. Evidenz – basierte Medizin mit Weibdorn – Extrakt [Research Based Medicine of Hawthorn Extracts]. Pharm Unserer Zeit 2005, 34(1): 58-64.
6. Koch E, Kohler S, Malek FA. Kardio – und vasoprotektive Eixgerschaften standardisierter Crataegus – Extrakte [Cardio and Vasoprotective Characteristics of Standardized Crataegus Extracts]. Pharm Unserer Zeit 2005, 34(1): 52-57.
7. Knašienė J. Magnis ir širdies ligos. Farmacija ir laikas. 2006. N1:78.
8. Locher R, Emmanuele L, Suter PM, Vetter W, Barton M. Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. Eur J Pharmacol. 2002 Jan 2, 434(1-2): 1-7.
9. Miller AL. Botanical Influences on Cardiovascular Disease. Altern Med Rew 1998, 3(6): 422-431.
10. Muller A, Linke W, Klaus W. Crataegus Extracts Blocks Potassium Currents in Guinea Pig Ventricular Cardiac Myocites. Planta Med 1999, 65: 335-339.
11. Verma SK, Rajeevan V, Jain P, Bordia A. Effect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary disease. Indian J Physiol Pharmacol. 2003 Jan, 49(1): 115-118.